Is there a difference between injecting and ingesting aluminum?
Ingested aluminum enters the blood from the gut. In the blood, ingested aluminum is in a water-soluble ionic form, typically Al3+ or an aluminum complex. This aluminum is separated into individual Al atoms, like ordinary salt dissolved in water. Ionic aluminum is toxic, but at normal, natural levels of exposure it does not cause harm, for a few reasons:
1) absorption is low. about 0.3% enters the blood,
2) it is blocked from entering the central nervous system (CNS) by the blood-brain barrier (BBB), and
3) it is rapidly filtered from the blood by the kidneys.
These defenses protect the body and brain from natural levels of aluminum ingestion.
Based on this understanding of ingested aluminum, it was long assumed that injected aluminum adjuvant nanoparticles (AAN'S) follow a similar pathway out of the body. Aluminum adjuvant nanoparticles cannot be filtered by the kidneys (they are too large). It was assumed that the AANs dissolve rapidly in body fluids, and the resulting Al3+ ions would be filtered out by the kidneys, just like ingested aluminum. However, this simple model appears wrong. This model is wrong because what actually happens is that a type of white blood cell called a macrophage (MF) ingests (called “phagocytosis”) the AANs before they can dissolve. Ingesting foreign material is normal behavior for MFs. When MFs detect bacteria or debris, the MFs ingest it, and destroy it with enzymes. The MFs then tell other immune system cells about the bacteria and how to detect it (called “antigen presentation”). MFs ingest many types of nanoparticles. Once inside the brain, the aluminum causes inflammation which attracts more MFs, some of which are loaded with still more aluminum. The result is a vicious cycle of inflammation and aluminum accumulation in the brain.
The problem is that AANs are not digested by the MF enzymes. The AANs remain inside the MFs for a long time. The AANs can persist years. MFs that consume the AANs become highly contaminated with aluminum, and spread the aluminum wherever they go. And they go everywhere in the body.
The MFs are able to travel across the blood brain barrier (BBB). The MFs, once loaded with AANs, act like a Trojan Horse and carry the AANs into the brain.
Concentrations of aluminum as low as 10-100 nano-molar can cause inflammation of brain tissue. 10 nano-molar is 270 nano-grams aluminum per liter. (nano = 1 billionth). That's an amazingly small amount.
10 nano-molar Al causes inflammation in human blood vessel cells (https://www.ncbi.nlm.nih.gov/pubmed/26265215)
100 nano-molar Al causes inflammation in human neurons (https://www.ncbi.nlm.nih.gov/pubmed/15961160)
A typical 1-year old infant has a brain weight of about 1000 grams. A 10 nano-molar concentration in 1000 grams requires 270 nano-grams (0.27 micrograms) of aluminum; a 100 nanomolar concentration in 1000 grams requires 2700 nano-grams (2.7 micrograms). This is extraordinary, because a single vaccine can contain 250 micrograms (250,000 nano-grams), and an infant can receive about 3,675 micrograms in the first 6 months. In other words, less than 0.01% of the aluminum in the first 6 months of vaccines can create a 10-nanomolar concentration in the brain, and 0.1% can create a 100-nanomolar concentration in the brain (since 3,675 x 0.01% = 0.3675 micrograms, and 3,675 x 0.1% = 3.675 micrograms)). A single vaccine contains far more than enough aluminum to inflame the brain.
There is also the Flarend study, which shows that even after a month, only about 6% (of Al hydroxide) or 22% (of Al phosphate) is eliminated in urine. Most aluminum adjuvant is retained in the body 1 month after injection. The Flarend study also shows that the aluminum spreads to numerous organs, including the brain. http://vaccinepapers.org/wp-content/uploads/Effect-of-Routine-Vaccination-on-Aluminum-and-Essential-Element-Levels-in-Preterm-Infants.pdf